SPRAVATO®
for Treatment-Resistant Depression
A Breakthrough Option When Traditional Antidepressants Aren’t Enough
For many people, depression doesn’t improve even after trying multiple medications. This can feel discouraging, exhausting, and isolating — but there are new options that bring real hope.
SPRAVATO® (esketamine) is an FDA-approved treatment specifically for treatment-resistant depression, meaning depression that hasn’t improved after trying at least two antidepressants.
Unlike traditional medications, SPRAVATO® works on a different part of the brain, helping reduce severe depressive symptoms and improve mood more rapidly.
Maryland Behavioral Health is proud to provide this innovative treatment in a safe, welcoming, and medically supervised environment.
Who Is SPRAVATO® For?
SPRAVATO® may be right for you if:
If this sounds familiar, SPRAVATO® may offer a new path forward.
How SPRAVATO® Works
SPRAVATO® is a nasal spray that works on glutamate, a neurotransmitter associated with mood, learning, and emotional regulation.
This is different from SSRIs and SNRIs, which focus on serotonin and norepinephrine.
Because SPRAVATO® acts differently, many patients experience:
Some individuals begin to feel relief within hours to days — not weeks.
Your SPRAVATO® Treatment Experience at Maryland Behavioral Health
Comfortable, Supervised Treatment Sessions
SPRAVATO® is taken in-office only under medical supervision.
During your session:
This allows us to ensure your safety and comfort.
Monitoring & Support
Our staff monitors:
You are never alone during the process.
Comprehensive Evaluation
Before treatment begins, our psychiatric provider completes a full assessment to ensure SPRAVATO® is safe and appropriate for you.
A Trusted Support Team
Our providers stay with you through every step — adjusting your plan as needed and guiding you through the full treatment course.
What to Expect After Treatment
After your session:
Your provider will continue to monitor progress and adjust your treatment plan as needed.
Treatment Schedule
SPRAVATO® typically follows this schedule:
Weeks 1–4
(Twice per week)
Initial stabilization period
Weeks 5–8
(Once per week)
Continued symptom improvement
Week 9 and beyond
(Every 1–2 weeks)
Maintenance phase based on your progress
Your provider may adjust timing based on your individual response.
Possible Side Effects
Most side effects are mild and temporary.
They may include:
All side effects are monitored by our clinical team during your visit.
Why Patients Choose SPRAVATO® at Maryland Behavioral Health
We combine modern medicine with personalized, patient-centered care.
We are available 24/7
Is SPRAVATO® Right for You?
If you’ve been struggling despite trying multiple medications, SPRAVATO® may be the breakthrough that finally brings relief.
You don’t have to live with treatment-resistant depression.
We’re here to help you explore new possibilities and reclaim your quality of life.